• Multiple Myeloma (MM) is a disease of the plasma cells, which comprise only 2-3% of cells in healthy blood.

• To increase the concentration of plasma cells in our myeloma FISH studies, we use a CD138+ selection protocol to isolate the target cells and identify genetic changes.

• IGH rearrangement is a common finding in MM FISH studies — Amoy Diagnostics' IGH reflex panel for IgH rearrangement study looks for the IGH partner gene to identify which chromosomes have translocated and help drive treatment decisions.

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Sample Requirements:

• Bone Marrow

  • 2-5 mL in a sodium heparin (green top) tube for all tests.

  • 5 mL in a EDTA (purple top) is acceptable for FISH testing only.

  • Minimum: 1 mL

• Storage: Room temperature if being shipped within 24 hours. Refrigerate if shipping will be delayed.

• Stability: Sample is optimum if received within 48 hours.

• Transportation: Room temperature (do not freeze or fix).